Flemoxin solutab packaging. Flemoxin Solutab - instructions for use, composition, indications, release form, side effects and price. Use during pregnancy and breastfeeding

This bactericidal agent belongs to the semi-synthetic penicillins. Effective against all kinds of microorganisms, including gram-negative ones (capable of resisting the action of antibiotics for a long time). The active substance, amoxicillin trihydrate, makes up 50% of the weight of the drug. In addition to it, the components are microcrystalline and dispersed cellulose, crospovidone, magnesium stearate, as well as flavoring additives.

Release form

The manufacturer produces Flemoxin in the form of white or light yellow tablets. Weighing 125, 250, 500 and 1000 mg, with engraving, respectively: 231, 232, 234, 236. The price in pharmacies depends on the size of the portions and ranges from 240 to 480 rubles. One package contains 20 tablets. Manufacturer: Japanese company Astellas. The medicine should be stored at a temperature of 15–25 °C.

Pharmacological action of the drug

Flemoxin prevents bacteria from creating cell membranes by blocking the main component of synthesis - peptidoglycan. This medication is quickly absorbed in the gastrointestinal tract. The convenience of its use is associated with the possibility of freely eating, even at the same time as the medicine, this will not affect the effect. Like any antibiotic, Flemoxin can only be used in accordance with a prescription prescribed by a doctor.

The effect of the medication begins soon after use, and reaches its maximum after an hour and a half. Taking 1000 mg of Flemoxin brings the concentration of the active substance in the blood to 8 mcg/l, in the gall bladder fluid - 25 mcg/l, in amniotic fluid during pregnancy - 2.5 mcg/l. These numbers increase in proportion to the dose.

A fifth of the active component interacts with blood proteins. The accumulation of the drug occurs in the internal membranes of hollow organs, bone tissue, fluid of the eye chambers, as well as in mucous secretions from the respiratory tract and lungs. The remainder of the substance continues to act in the body, creates additional protection against infection and speeds up recovery.

The therapeutic compound does not pass through the BBB (barrier between the circulatory system and the central nervous system). But with meningitis, it enters the cerebrospinal fluid in sufficient quantities.

The half-life of the drug in adults is from one to one and a half hours, in newborns and infants it is 3 times longer. 90% of the substance leaves the body within 8 hours, of which two thirds are excreted in the urine. Most of the metabolic products of amoxicillin have no effect on the body.

What does it help with?

Flemoxin successfully fights against various types of streptococci, tetanus and Haemophilus influenzae, Moraxella, Listeria, Helicobacter pylori. Can be used against fecal enterococcus, Proteus mirabilis, Salmonella (causing typhoid fever), Shigella Sonne, Vibrio cholerae. Does not affect microorganisms capable of synthesizing beta-lactamase. These include Pseudomonas aeruginosa, some Proteus, and Enterobacteriaceae.

List of indications:

Bronchial, tracheal and pulmonary diseases. For example, flu, sinusitis, sinusitis.
Inflammatory pathologies of the kidneys (pyelonephritis), bladder (cystitis), skin (furunculosis, streptoderma, erysipelas), bone tissue (osteomyelitis), and gastrointestinal tract.
Some gynecological diseases (adnexitis).
Together with other medications, it helps to cope with infectious mononucleosis, blood poisoning, and abscesses.
Used after surgery to prevent complications.

How to take for adults

The individual dosage is influenced by factors such as the severity of the disease, the susceptibility of this type of microorganism to the drug, and the age of the patient. An adult takes 1000–4000 milligrams of medication per day in two servings.

The course of treatment for mild to moderate infections lasts no more than a week. This period increases to 10 days for streptococcal infection. If the disease has subsided, you can stop taking it only on the third day after the symptoms disappear.

Directions for use and dosage, official instructions

How to take for children

Children's dosage is calculated based on body weight. For each kilogram, about 40 mg of the substance per day is required for moderate severity of the disease and up to 180 for complications. A child over 10 years old should be given two servings of 500 or 1000 milligrams. For younger children, doses of 250 mg are used, taken 3 times a day. Children 1–3 years old are given 125 milligrams three times a day.

Tablets are taken both before and after meals. The way they enter the body can be either swallowing whole, chewing with a glass of water, or preparing a syrup or suspension. The soluble form of Solutab is convenient for its pleasant taste (thanks to the lemon-tangerine filler) and rapid absorption.

Dosage regimen for angina

This disease is caused by staphylo- and streptococci, very resistant microorganisms. Only some antibiotics can effectively destroy them. A sore throat is accompanied by symptoms similar to a cold: high fever, sore throat, chills, weakness.

A study that reveals the sensitivity of pathogenic flora to medications requires time, which may not be available in the case of an acute form of the disease. Flemoxin would be a good solution, since it acts quickly, is universal and has mild side effects (compared to other bactericidal agents).

Children over 10 years of age and adults need to take about 1000-4000 milligrams of medication per two servings per day. It is better to dissolve the product in water; the child will readily drink this suspension with a pleasant smell. Inhalations will help as an additional way to relieve inflammation.

The course of treatment for mild to moderate infections lasts no more than a week. In cases where no improvement is observed within two days, the doctor should prescribe another antibiotic. After recovery, it is recommended to undergo probiotic therapy to restore the natural balance of microorganisms in the intestines.

Dosage regimen for sinusitis

This disease is an inflammation of the air-filled cavities connected to the nose. Symptoms: chills, fever, mucus and purulent discharge, pressure in the bridge of the nose, headache when bending or clenching the teeth. If left untreated, this disease can become chronic and cause vision problems, otitis, meningitis, periostitis, systemic inflammation of the body (sepsis).

The disease can be caused by bacteria, viruses, fungi, and allergic reactions. The presence of pus highly likely indicates a microbial source of infection. It is in the case of a bacterial infection that the antibiotic is extremely effective. If the disease is caused by fungi, its use is contraindicated, and it has no effect on viruses. The instructions for use advise taking 2000–3000 milligrams of the medicine in two servings. The allergic form of sinusitis, as well as sometimes the viral form, go away on their own.

Reception for cystitis

A common bladder disease can also be effectively treated with Flemoxin. In terms of the frequency of occurrence of the pathology, women and girls are in first place, children are in second; men are rarely infected with cystitis. Since inflammation of the bladder walls is caused by bacteria, antibiotic therapy becomes indispensable. It is recommended to take two tablets of Flemoxin Solutab 500 mg or 1000 mg per day.

Since cystitis can also be caused by bacteria that are insensitive to the product, it is necessary to do a urine test to identify the pathogen. In some cases, the sources of the disease are viruses, which means Flemoxin will not help. During pregnancy, not only the bladder, but also the kidneys become inflamed (pyelonephritis). In this case, there is a risk of miscarriage.

Antispasmodics (No-shpa, Drotaverine). They make pain easier to bear.
Antipyretics (Paracetamol). It is advisable to use only at temperatures above 38 °C.
Complex action medications such as Urolesan and Canephron. They relieve inflammation, help against germs and relieve pain.

Also useful:

Drink up to 3 liters of liquid during the day (pathogenic microbes are excreted along with urine).
Follow a diet. Salt and hot spices cause irritation in the mucous membranes.
Apply a heating pad to the lower abdomen.

Flemoxin Solutab and alcohol

Using the drug with alcoholic beverages is unacceptable, as this weakens the body's defense systems. Reduced immunity does not allow a person to normally resist the disease. As a result, the side effects indicated in the annotation appear much more intense. The digestive system becomes upset, attacks of severe nausea and vomiting appear, and sometimes appetite disappears. Added to this is the destructive effect on the liver and kidneys. Malignant tumors in the organs of the genitourinary system are possible.

Contraindications

It should not be taken by people who are sensitive to medications based on penicillin and cephalosporin or to any of its components.
It is not recommended to take during pregnancy and breastfeeding, except in situations where other methods do not help.

Side effects

Undesirable effects of treatment depend on the duration of taking the drug, the age of the patient and the individual characteristics of his body.

Most often the digestive system reacts negatively to this drug. In such cases, an increase or decrease in appetite, diarrhea, nausea and vomiting are observed. These symptoms may indicate an overdose of the drug. Occasionally, acute diarrhea with blood occurs, this is a sign of hemorrhagic colitis.
If the patient is prone to allergies, swelling and peeling of the hands and face, nettle fever, and a rash with itching are possible.
Tremors of the limbs, dizziness, and possible fainting occur less frequently.
In rare cases, cough, narrowing of the bronchi, and Quincke's edema are observed.
If the patient has mononucleosis or a malignant lesion of the lymphatic tissue, a skin rash appears in most cases. This phenomenon occurs regardless of the patient's sensitivity to penicillin. In case of such a reaction, there is no need to stop taking the drug.
There is also the possibility of superinfection.
Resisting the effects of penicillins, microorganisms develop cross-resistance to cephalosporins.
When treating cystitis, inflammatory processes in the kidneys of a non-infectious nature are possible.

Interaction with other substances

Bactericidal medications like Rifampicin enhance the effect of the drug.
The drugs Probenecid, Phenylbutazone and Xifenbutazone reduce the half-life rate of amoxicillin, and accordingly its concentration in the blood increases.
Flemoxin sometimes reduces the effectiveness of birth control pills when used simultaneously.
If you use drugs with it that suppress the ability of bacteria to reproduce (tetracycline group, macrolides, Chloramphenicol), this may negatively affect its action.

Analogs

In addition to amoxyllicin, the active substance is clavulanic acid, which allows the product to effectively cope with bacteria that produce beta-lactamase. This occurs by slowing down the production of a protective enzyme by microorganisms. Available in the form of tablets, syrup, injection powder, dry substance for the preparation of drops and suspension.

Flemoxin has a broad spectrum of action. Belongs to the group of penicillins. Used to treat infectious and inflammatory diseases. This drug has a detrimental effect on many pathogenic microorganisms.

The drug is based on a semi-synthetic antibiotic – amoxicillin. This antibiotic belongs to the group of penicillins. In its chemical structure and degree of activity it is similar to ampicillin.

It should be remembered that when using Flemoxin simultaneously with other bactericidal drugs, the therapeutic effect is enhanced.To eliminate the disease, it is important to complete the full course of treatment with the drug. It is prohibited to use Flemoxin on your own, as adverse reactions may occur.

There are specific guidelines for using the drug. If individual intolerance to amoxicillin is observed, the drug should not be taken for the treatment of various infectious diseases. In this case, the doctor will select another medicine.

Restrictions on the use of the drug:

According to the instructions, the drug should not be taken by people with kidney failure and ulcerative colitis.
Flemoxin is prescribed with caution to people with gastrointestinal pathologies, lymphocytic leukemia or infectious mononucleosis. Substances included in the drug may cause exacerbation of the above diseases.
An antibiotic is prescribed only if the risk to the fetus from the drug is less than the expected benefit to the mother. It is not recommended to use Flemoxin during lactation.

The antibacterial drug is well tolerated in the treatment of various infectious diseases. However, if the dosage specified in the instructions is not followed, adverse reactions may occur:

While taking the drug, headache, nausea, and diarrhea may occur. After antibiotic treatment, women may develop a fungal infection. In rare cases, the patient may complain of vomiting and abdominal pain.
Allergic reactions in the form of skin rashes, urticaria, dermatitis, etc. are also possible.
Taking Flemoxin can lead to pseudomembranous colitis. This is a fairly serious adverse reaction caused by clostridia. Colitis causes severe diarrhea, which causes the body to become severely dehydrated.

If some adverse reactions occur, you should notify your doctor and stop taking the drug. If necessary, symptomatic therapy is carried out. Taking this into account, the doctor will prescribe another medicine.

Interaction with other drugs

If your doctor has prescribed Flemoxin to treat an infectious disease, you must warn him about what medications you are already taking. When some drugs interact, various reactions may occur.

The simultaneous use of Flemoxin and contraceptive drugs leads to a decrease in the desired therapeutic effect of the latter. In this case, there is a risk of appearance.Ascorbic acid increases the absorption of the active substance Flemoxin.

The absorption of the antibiotic is reduced when used together with laxatives, as well as drugs that reduce gastric acidity.The combination of Flemoxin and Alopurinol can lead to skin rashes.The level of antibiotic in the blood plasma increases with the simultaneous use of Phenylbutazone, Probenecid, Oxyphenabutazone, and non-steroidal anti-inflammatory drugs.

Analogues of the drug

There are drugs Flemoxin, which are similar in composition and properties.

Popular analogues of Flemoxin include:

Amoxil. wide spectrum of action. It is available in the form of a solution and tablets, so it can be administered intravenously and taken orally. The dosage for children is 250 mg, for adults from 250 to 500 mg.
Amosin. Antimicrobial semisynthetic drug. Used for acute infectious diseases of the upper and lower respiratory tract, diseases of the digestive tract, urogenital infections, meningitis, borreliosis. The antibiotic is contraindicated for allergic diathesis, bronchial asthma, hay fever, and severe digestive disorders. The drug is not prescribed to children under 3 years of age.
Gonoform. An antibacterial drug that prevents the growth and division of pathogenic bacteria. Available in the form of granules, and. Helps get rid of infectious diseases.
Ospamox. Antibiotic of the penicillin group. Can be used during asymptomatic bacteriuria, cystitis, pyelonephritis. Also used to treat gynecological infections.
Danemox. Bactericidal drug. Has the same properties as Flemoxin Solutab. Available in tablets with the active ingredient of 250 mg and 500 mg. Dispensed with a doctor's prescription.
Amoxisar. The antibiotic can be used to treat infectious diseases in both children and adults. The medicine is administered intravenously, intramuscularly or orally. The duration of treatment depends on the severity.
Hiconcil. The drug has a wide spectrum of bactericidal action. Used to treat diseases caused by various pathogenic bacteria. Contraindicated for use during pregnancy, renal failure, mononucleosis. Convenient to use for children in the form.
Other analogs of antibiotics Flemoxin: Ecobol, Gramox-D, Iramox, Baktos, V-Mox, etc.

Of the large number of the above analogues of Flemoxin Solutab, the only domestic analogue is Gramox-D. For treatment, they do not always buy imported medicine, which is several times more expensive than the domestic drug.

Antibacterial drugs should only be prescribed by a qualified specialist. You should know that many Flemoxin analogs have different side effects, although the therapeutic effect is the same.

Flemoxin solutab is from the group of penicillins. Its active ingredient is amoxicillin. This antibiotic is prescribed for the treatment of a wide variety of inflammatory and infectious diseases, and it can be taken by both adults and children.

Features of the drug

Flemoxin solutab has a bactericidal effect. It disrupts the synthesis of protein in the microbial cell wall, which leads to the destruction and death of the bacterium.

Flemoxin is available in tablets of various dosages. After taking the tablet orally, the drug is absorbed quickly and almost completely. Flemoxin solutab begins to have its effect after fifteen to thirty minutes. The maximum concentration of the drug is reached after one to two hours.

Note! It is noteworthy that food intake does not actually affect the absorption of the drug. Therefore, unlike many other antibiotics, Flemoxin Solutab is taken without taking into account when the person will eat. The medicine can be taken before or after meals and even directly during the meal.

The tablet can be taken whole with water. For those people who find it difficult to swallow tablets, you can chew the antibiotic or even dissolve it in a small amount of water (20-100 ml), as written in the instructions for the drug.

Analogues of Flemoxin solutab:

Amoxicillin;
Amoxil;
Amofast;
Graximol;
Amosin.

Indications for use

Flemoxin solutab belongs to the broad antimicrobial spectrum. It is especially effective against many bacteria: strepto- and staphylococci, clostridia, neisseria, enterococci, E. coli, Shigella, salmonella. Flemoxin solutab is prescribed for any inflammatory and infectious diseases caused by microbes sensitive to amoxicillin:

Treatment regimen

The prescribed dosage of Flemoxin depends on the severity of the disease, as well as the age of the patient.

P For inflammatory and infectious diseases of mild to moderate severity, Flemoxin should be taken for five to seven days. For diseases caused by streptococcus pyogenes, the course of treatment should last at least ten days.

In general, it is necessary to focus on the clinical picture of the disease and the body’s reaction to the administration of the drug. Flemoxin must be continued to be taken for another two days after the signs of the disease disappear.

For inflammatory and infectious diseases of mild and moderate severity, adults and children over ten years of age are prescribed the medicine in a daily dosage of 1-1.5 g, which is divided into two or three doses during the day. For severe infections, the medication is prescribed in a daily concentration of 2.25-3 grams, divided into three doses.

Flemoxin is successfully used in pediatric practice. For young children, the dosage of Flemoxin is much less:

Contraindications, side effects

Flemoxin is not prescribed to people with hypersensitivity to penicillin drugs, or if the patient already has hypersensitivity. It is known that the use of penicillins, in particular Flemoxin, in diseases such as lymphocytic leukemia provokes the appearance of a skin rash - exanthema. And although exanthema does not pose a danger to humans, Flemoxin is still taken with extreme caution in case of infectious mononucleosis and lymphocytic leukemia.

It is not recommended to take the medicine for pregnant women. Flemoxin is prescribed to pregnant women only when it is really impossible to do without it. Laboratory tests have shown that the medicine passes into breast milk in small quantities. Therefore, it should not be taken if the mother is breastfeeding.

The most common side effect during treatment with penicillins and in particular Flemoxin Solutab is the development of an allergic reaction. can only manifest itself as skin rashes accompanied by itching. More severe forms of allergies occur with swelling of the mucous membranes, damage to the kidneys, joints and other disorders. A severe and rapidly progressing form of allergy can be considered, the symptoms of which are swelling of the larynx, suffocation, drop in blood pressure, and pale skin. Fortunately, anaphylactic shock is extremely rare.

Name: Flemoxin Solutab

Name: Flemoxin Solutab

Indications for use:
Infections caused by bacteria sensitive to amoxicillin (diseases of the genitourinary system, respiratory system, gastrointestinal tract, infections of soft tissues and skin).

Pharmachologic effect:
Broad-spectrum antibacterial agent. The active ingredient of Flemoxin Solutab is amoxicillin trihydrate (semi-synthetic penicillin, beta-lactam antibacterial agent). Has a bactericidal effect. Effective against gram-negative and gram-positive bacteria, such as: S. pneumoniae, Streptococcus pyogenes, Clostridium tetani, Neisseria gonorrhoeae, C. welchii, N. meningitidis, Moraxella catarralis, Staphylococcus aureus, Bacillus anthracis, Staphylococcus spp, Listeria monocytogenes, Haemophilus influenzae, Helicobacter pylori. It is less effective against pathogens of intestinal infections: Escherichia coli, Shigella sonnei, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Vibrio cholere. Inactive against microorganisms that produce beta-lactamase, as well as against indole-positive Proteus, Pseudomonas, Enterobacter.

The peculiarity of the dosage form (Solyutab) ensures, after oral administration, rapid absorption in the gastrointestinal tract and complete (over 93%) absorption. Taking with food is not accompanied by changes in the absorption of the active ingredient of the product. The maximum concentration of amoxicillin in the blood plasma is detected after 60-120 minutes. after reception. When taking Flemoxin Solutab, a higher maximum concentration of amoxicillin in the blood plasma is observed than when taking the insoluble dosage form of this antibiotic. Acid-stable active substance.

After internal administration of amoxicillin at a dose of 375 mg, Cmax in blood plasma is observed after 120 minutes (6 μg/l). The maximum concentration of amoxicillin in the product Flemoxin Solutab increases by 2 times if the dose taken is 2 times higher than 375 mg. Amoxicillin is bound to plasma proteins in an amount of 20% of the administered dose. Accumulation of the antibiotic when prescribing therapeutic doses of the product occurs in bone tissue, mucous membranes, intraocular fluid, and sputum. In bile, there is an increase in the concentration of amoxicillin compared to its level in the blood by 2-4 times. Approximately 25-30% of amoxicillin (compared to the content in the blood) is determined in the umbilical vessels and within the fetal fluid. Despite the insufficient passage of amoxicillin through the blood-brain barrier, 20% of amoxicillin from its concentration in the blood plasma is determined in the cerebrospinal fluid during meningitis.

In the body it is partially metabolized to inactive metabolites. Excreted by the kidneys: 20% by glomerular filtration and 80% by tubular excretion. After 8 hours of taking the product, 90% of the active substance is excreted in the urine (and unchanged - 60-70%).

In childhood (up to 6 months, in premature babies), the half-life of amoxicillin is 3-4 hours. In the case of normal kidney function, the half-life of the active substance is 1-1.5 hours. With impaired renal function (creatinine clearance - 15 ml/min or less), the half-life increases and can reach up to 8.5 hours with anuria. If liver function is impaired, the half-life does not change.

Flemoxin Solutab method of administration and dosage:
Flemoxin Solutab has a pleasant tangerine-lemon taste. The tablets are swallowed without chewing and taken before or after meals. You can divide the tablet into several parts and chew it with water. It is also possible to dissolve the tablet in water (20 ml to obtain a syrup, 100 ml to obtain a suspension).

Flemoxin Solutab is prescribed for bacterial infections of mild to moderate severity at a dose of 0.5-2 g per day, the daily dose divided into 2 doses (for adults). In pediatrics, it is prescribed to children from 1 year of age: from 1 year to 3 years – 0.125 g 3 times a day or 0.25 g 2 times a day; from 3 to 6 years - 0.25 g 3 times a day or 1.375 g 2 times a day. The course of treatment is 5-7 days. For streptococcal infections, it is recommended to take the product for 10 days. Approximately, children are prescribed the product at the rate of 30-60 mg/kg body weight per day, divided into 2-3 doses. The dosage is prescribed by the doctor individually, depending on age, general condition, severity of the disease and sensitivity of microorganisms to amoxicillin.

In case of severe infections, or for recurrent, chronic diseases, use a dose of 0.75-1 g 3 times a day. In pediatrics – 60 mg/kg body weight (divided into 3 doses.)

For eradication of Helicobacter pylori infection: 2 g/s (divided into 2 doses).
For uncomplicated acute gonorrheal infection - 3 g per 1 dose in combination with probenecid (1 g).

If renal function is impaired with creatinine clearance less than 10 ml/min, the dosage is reduced by 15-50%.
Reception of Flemoxin Solutab should continue after the disappearance of signs of the disease for another 2 days.

Flemoxin Solutab contraindications:
Allergic reaction to antibacterial products of the penicillin and cephalosporin series, as well as to additional substances Flemoxin Solutab.

Flemoxin Solutab side effects:
Rare side effects: itching in the anal area, diarrhea, interstitial nephritis; thrombocytopenia, hemolytic anemia, agranulocytosis, allergic skin reactions in the form of a small papular rash.
Very rare: hemorrhagic and pseudomembranous colitis, Steven Johnson syndrome, erythema multiforme, Quincke's edema, anaphylactic shock.

Pregnancy:
Flemoxin Solutab is not contraindicated for pregnant and nursing mothers.

Overdose:
An overdose of Flemoxin Solutab may have the following symptoms: vomiting, nausea, diarrhea. Vomiting and diarrhea can cause dehydration of the body and disruption of water and electrolyte balance. In case of overdose, enterosorbents, saline laxatives, and hydration measures are prescribed.

Use with other medications:
Inhibition of the tubular excretion of amoxicillin is observed when combined with phenylbutazone, probenecid, oxyphenbutazone, and, to a lesser extent, acetylsalicylic acid and sulfinpyrazone. This may lead to increased plasma concentrations of amoxicillin and an increase in its half-life.

A decrease in the effectiveness of hormonal contraceptives when combined with amoxicillin was found.
Unlike ampicillin, the combination of amoxicillin with allopurinol does not increase the incidence of skin reactions.
Bacteriostatic antibacterial agents (macrolides, tetracyclines, chloramphenicol) neutralize the bactericidal effect of amoxicillin.

Release form:
Tablets 125; 250; 500; 1000 mg. Tablets are white or white-yellow, oblong in shape. Engravings: for tablets 125 mg – “231”; 250 mg – “232”; 500 mg – “234”; 1000 mg – “236”. On one side of the tablet is the logo of the manufacturer, on the other - the risk. Contains 20 tablets in a contour coating.

Storage conditions:
Do not use after the date indicated on the pack. Store at room temperature.

Flemoxin Solutab composition:
Active substance: amoxicillin trihydrate.
Additional components: microcrystalline cellulose, dispersed cellulose, vanillin, crospovidone, saccharin, tangerine flavor, lemon flavor, magnesium stearate.

Additionally:
It has been shown that when patients with lymphocytic leukemia or infectious mononucleosis are prescribed penicillin products, a skin rash often develops -
exanthema (60-100%), which is not due to hypersensitivity to the product. A similar effect in the life history is not a contraindication to the prescription of penicillins, incl. and amoxicillin.

Attention!
Before using the medication "Flemoxin Solutab" You should consult your doctor.
The instructions are provided for informational purposes only. Flemoxin Solutab».

Flemoxin Solutab

Compound

Active substance: amoxicillin trihydrate.
Additional components: microcrystalline cellulose, dispersed cellulose, vanillin, crospovidone, saccharin, tangerine flavor, lemon flavor, magnesium stearate.

pharmachologic effect

Broad-spectrum antibacterial agent. The active ingredient of Flemoxin Solutab is amoxicillin trihydrate (semi-synthetic penicillin, beta-lactam antibacterial agent). Has a bactericidal effect. Effective against gram-negative and gram-positive bacteria, such as: S. pneumoniae, Streptococcus pyogenes, Clostridium tetani, Neisseria gonorrhoeae, C. welchii, N. meningitidis, Moraxella catarralis, Staphylococcus aureus, Bacillus anthracis, Staphylococcus spp, Listeria monocytogenes, Haemophilus influenzae, Helicobacter pylori. It is less effective against pathogens of intestinal infections: Escherichia coli, Shigella sonnei, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Vibrio cholere. Inactive against microorganisms that produce beta-lactamase, as well as against indole-positive Proteus, Pseudomonas, Enterobacter.

The peculiarity of the dosage form (Solyutab) after oral administration ensures rapid absorption in the gastrointestinal tract and complete (over 93%) absorption. Taking with food is not accompanied by changes in the absorption of the active substance of the drug. The maximum concentration of amoxicillin in the blood plasma is detected 60-120 minutes after administration. When taking Flemoxin Solutab, a higher maximum concentration of amoxicillin in the blood plasma is observed than when taking the insoluble dosage form of this antibiotic. Acid-stable active substance.

After internal administration of amoxicillin at a dose of 375 mg, Cmax in blood plasma is observed after 120 minutes (6 μg/l). The maximum concentration of amoxicillin in the drug Flemoxin Solutab increases by 2 times if the dose taken is 2 times higher than 375 mg. Amoxicillin is bound to plasma proteins in an amount of 20% of the administered dose. Accumulation of the antibiotic when prescribing therapeutic doses of the drug occurs in bone tissue, mucous membranes, intraocular fluid, and sputum. In bile, there is an increase in the concentration of amoxicillin compared to its level in the blood by 2-4 times. Approximately 25-30% of amoxicillin (compared to the content in the blood) is determined in the umbilical vessels and amniotic fluid. Despite the insufficient passage of amoxicillin through the blood-brain barrier, 20% of amoxicillin from its concentration in the blood plasma is determined in the cerebrospinal fluid during meningitis.

In the body it is partially metabolized to inactive metabolites. Excreted by the kidneys: 20% by glomerular filtration and 80% by tubular excretion. 8 hours after taking the drug, 90% of the active substance is excreted in the urine (and unchanged - 60-70%).

Indications for use

Infections caused by bacteria sensitive to amoxicillin (diseases of the genitourinary system, respiratory system, gastrointestinal tract, infections of soft tissues and skin).

Mode of application

Flemoxin Solutab has a pleasant tangerine-lemon taste. The tablets are swallowed without chewing and taken before or after meals. You can divide the tablet into several parts and chew it with water. It is also possible to dissolve the tablet in water (20 ml to obtain a syrup, 100 ml to obtain a suspension).

Flemoxin Solutab is prescribed for bacterial infections of mild to moderate severity at a dose of 0.5-2 g per day, the daily dose divided into 2 doses (for adults). In pediatrics, it is prescribed to children from 1 year of age: from 1 year to 3 years – 0.125 g 3 times a day or 0.25 g 2 times a day; from 3 to 6 years - 0.25 g 3 times a day or 0.375 g 2 times a day. The course of treatment is 5-7 days. For streptococcal infections, it is recommended to take the drug for 10 days. Approximately, children are prescribed the drug at the rate of 30-60 mg/kg body weight per day, divided into 2-3 doses. The dosage is prescribed by the doctor individually, depending on age, general condition, severity of the disease and sensitivity of microorganisms to amoxicillin.

In case of severe infections, or for recurrent, chronic diseases, use a dose of 0.75-1 g 3 times a day. In pediatrics – 60 mg/kg body weight (divided into 3 doses).

For eradication of Helicobacter pylori infection: 2 g/s (divided into 2 doses).
For uncomplicated acute gonorrheal infection - 3 g per 1 dose in combination with probenecid (1 g).

If renal function is impaired with creatinine clearance less than 10 ml/min, the dosage is reduced by 15-50%.
Taking Flemoxin Solutab should continue after the signs of the disease disappear for another 2 days.

Side effects

Rare side effects: itching in the anal area, diarrhea, interstitial nephritis; thrombocytopenia, hemolytic anemia, agranulocytosis, allergic skin reactions in the form of a small papular rash.
Very rare: hemorrhagic and pseudomembranous colitis, Steven Johnson syndrome, erythema multiforme, Quincke's edema, anaphylactic shock.

Contraindications

Allergic reaction to antibacterial drugs of the penicillin and cephalosporin series, as well as to additional substances Flemoxin Solutab.

Pregnancy

The use of the drug during pregnancy and lactation is allowed only in cases where the potential benefits of therapy for the mother outweigh the risk of side effects in the fetus or infant.

Drug interactions

Inhibition of the tubular excretion of amoxicillin is observed when combined with phenylbutazone, probenecid, oxyphenbutazone, and, to a lesser extent, acetylsalicylic acid and sulfinpyrazone. This may lead to increased plasma concentrations of amoxicillin and an increase in its half-life.

Overdose

An overdose of Flemoxin Solutab may have the following symptoms: vomiting, nausea, diarrhea. Vomiting and diarrhea can cause dehydration of the body and disruption of water and electrolyte balance. In case of overdose, enterosorbents, saline laxatives, and hydration measures are prescribed.

Release form

Tablets 125; 250; 500; 1000 mg. Tablets are white or white-yellow, oblong in shape. Engravings: for tablets 125 mg – “231”; 250 mg – “232”; 500 mg – “234”; 1000 mg – “236”. On one side of the tablet is the logo of the manufacturer, on the other - the risk. Contains 20 tablets in a contour coating.

Storage conditions

Do not use after the date indicated on the package. Store at room temperature.

ATX:

J01CA04

Manufacturer:

Astellas Pharma

Additionally

It has been shown that when patients with lymphocytic leukemia or infectious mononucleosis are prescribed penicillin drugs, a skin rash often develops -
exanthema (60-100%), which is not due to hypersensitivity to the drug. A similar effect in the life history is not a contraindication to the prescription of penicillins, incl. and amoxicillin.

Allergic reactions when taking ampicillin occur more often than when using penicillins, but less often than when taking ampicillin.
Cross-resistance is observed between antibacterial agents of the cephalosporin and penicillin series.
There is a risk of developing superinfection, as in the case of prescribing penicillins.
At the first signs of pseudomembranous colitis (severe diarrhea), appropriate treatment is necessary. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.